PATHOLOGY

Detailed explanation-1: -Keratinocytes produce keratin, a tough, protective protein that makes up the majority of the structure of the skin, hair, and nails. The squamous cell layer is the thickest layer of the epidermis, and is involved in the transfer of certain substances in and out of the body.

Detailed explanation-2: -Hair is composed of 95% keratin, a fibrous and helical protein (in the shape of a helix), which is part of the composition of the skin and of all the phanera (hair, nails, etc.). Synthesized by keratinocytes, keratin is insoluble in water, thus ensuring waterproofing and protection for hair.

Detailed explanation-3: -As the primary cell type in the epidermis, keratinocytes produce large amounts of cytokines to initiate and regulate inflammation, including IL-1, -6, -7, -8, -10, -12, -15, -18, and-20, and TNF- [158].