PATHOLOGY

Detailed explanation-1: -In Metabolism, the heat is released in the form of chemical reactions and also in the form of cellular respiration. The liver is the major source of metabolic heat. The other source is the brain that uses 20% of the glucose processed in the human body.

Detailed explanation-2: -Heat is generated on a cellular level by metabolism. The basal metabolic rate increases by thyroid hormone, sympathetic stimulation, muscle activity, and chemical activity within cells.

Detailed explanation-3: -The oxidation of metabolic fuels such as carbohydrate and fatty acids in the mitochondria of the muscle fibres produces adenosine triphosphate. Through the hydrolysis of adenosine triphosphate, energy is released to support muscle contraction. However, the hydrolysis of adenosine triphosphate also releases heat.

Detailed explanation-4: -The metabolic heat generated by a person increases as a function of the physical work performed. Metabolic heat can be estimated based on actual measurement of oxygen consumption of a worker, or estimated using detailed calculations and tabulations.