PATHOLOGY

Detailed explanation-1: -Reticular dermis: The reticular layer is the bottom layer of your dermis. It’s thick, and it contains blood vessels, glands, hair follicles, lymphatics, nerves and fat cells.

Detailed explanation-2: -Using immunohistochemical procedures numerous nerve fibers have been found in all cell layers of human epidermis. These nerves originate from nerve trunks in the dermis, enter the epidermis, then divide distally to eventually end in small enlargements, near the surface of the skin and in deeper areas.

Detailed explanation-3: -The epidermis is innervated with sensory nerves. These nerves sense and transmit heat, pain, and other noxious sensations. When they are not functioning properly sensations such as numbness, pins-and-needles, pain, tingling, or burning may be felt.