PATHOLOGY

Detailed explanation-1: -The dermis is held together by a protein called collagen. This layer gives skin flexibility and strength. The dermis also contains pain and touch receptors.

Detailed explanation-2: -Dermis Layers: Reticular Layer of the Dermis The reticular layer of the dermis is the thick deep layer that contains dense connective tissue. The reticular layer has blood vessels and nerve endings that allow the skin to feel warm and sense pain. Elastin fibers provide the skin’s elasticity.

Detailed explanation-3: -The neuroimmunocutaneous system (NICS) is responsible for the cutaneous sensations of touch, pressure, temperature, and pain. This sensory transduction occurs via primary afferent nerves following reciprocated signals between neuronal and nonneuronal skin cells of the NICS [1].

Detailed explanation-4: -Pain Receptors are also called free nerve endings. These simple receptors are found in the dermis around the base of hair follicles and close to the surface of the skin (epidermis) where the hair emerges from the skin.