PATHOLOGY

Detailed explanation-1: -Because carotene is excreted by sebaceous glands and is present in sweat, the yellow pigmentation is particularly noticeable in areas where sweating is marked. Yellow pigmentation often appears first on the tip of the nose, palms, soles, and nasolabial folds, extending gradually over the entire body.

Detailed explanation-2: -Carotenes can be found in many dark green and yellow leafy vegetables and appear as fat soluble pigments, while -carotene can be found in yellow, orange and red colored fruits and vegetables [44].

Detailed explanation-3: -The primary factor differentiating carotenoderma from jaundice is the characteristic sparing of the sclerae in carotenoderma, which would be involved in jaundice if the bilirubin is at a level to cause skin findings. In contrast to jaundice, carotenoderma is reported to be better observed under artificial light.