PATHOLOGY

Detailed explanation-1: -Most of the glucose entering the tubular system is reabsorbed along the nephron segments, primarily in the proximal tubule, such that urine is almost free of glucose. This is different in diabetes, where the filtered glucose exceeds the transport capacity of the tubular system for glucose and glucosuria occurs.

Detailed explanation-2: -SGLT1, which are found in the straight section of the proximal tubule (S3), are responsible for approximately 10% of glucose reabsorption. The other 90% of filtered glucose is reabsorbed through by SGLT2, which are located in the convoluted section on the proximal tubule (S1)[5] [Table 1].

Detailed explanation-3: -The kidneys continuously filter large quantities of glucose. Glucose is a valuable energy substrate and the tubular system of the kidney, particularly the proximal tubule, has evolved to reabsorb and retain basically all the filtered glucose.