PATHOLOGY

Detailed explanation-1: -The PCT is responsible for reabsorbing most of the glucose, amino acids, and small peptides that enter the ultrafiltrate (Berry and Rector 1991). The PCT contains numerous secondary active, sodium-coupled transporters for glucose (SGLT2) and amino acids (Silbernagl and Gekle 2008; Silverman 2008).

Detailed explanation-2: -Amino acids are reabsorbed from the tubular lumen by a saturable, carrier-mediated, concentrative transport mechanism driven by a Na+ electrochemical gradient across the luminal membrane.

Detailed explanation-3: -Active transport is the key to the reabsorptive processes in the proximal tubule. Glucose and amino acids are reabsorbed across the apical membrane of the proximal tubule by sodium-coupled secondary active transport.