PATHOLOGY

Detailed explanation-1: -Small amounts of protein in the urine may be an early sign of kidney damage due to diabetes. Such small amounts may not be detected by dipstick . In these cases, urine will need to be collected over a period of 12 or 24 hours and tested by a laboratory.

Detailed explanation-2: -Glycosuria in Diabetes Diabetes causes glycosuria because there either isn’t enough insulin, or your body can’t use what’s available. WIthout insulin, blood glucose levels become too high, and your kidneys can’t filter and reabsorb it. Your body gets rid of the excess through your urine.

Detailed explanation-3: -The inherited form of this disorder is called familial renal glucosuria (FRG) (PRG; OMIM #233100). FRG is a rare disorder due mainly to mutations in the sodium-glucose cotransporter 2 gene (SGLT2) that are responsible for the majority of cases.

Detailed explanation-4: -In most people with Renal glycosuria, there are no apparent symptoms or serious effects. Rare cases of polyuria (increased urine output), enuresis (involuntary urination), and mild delays in growth and maturation during puberty have been reported.