PATHOLOGY

Detailed explanation-1: -Clearance is equal to the rate at which a drug is removed from plasma(mg/min) divided by the concentration of that drug in the plasma (mg/mL). The total ability of the body to clear a drug from the plasma is renal clearance plus hepatic clearance plus clearance from all other tissues.

Detailed explanation-2: -For any substance, renal clearance is defined as the volume of blood from which that substance is removed (cleared) by the kidneys per unit time.

Detailed explanation-3: -For normal kidneys, the renal plasma flow is 625 mL/min while the glomerular filtration rate is 125 mL/min. Since the tubular portion of the nephron can secrete and reabsorb substances, there are only two ways by which a given substance can be cleared by the nephron (end up in the urine).

Detailed explanation-4: -Renal clearance of a substance refers to how quickly a particular substance is removed from the plasma by the kidney and excreted in urine. So something with a high renal clearance means that it will be quickly removed from the blood, and vice versa.