PATHOLOGY

Detailed explanation-1: -Erythropoietin is a hormone that your kidneys naturally make to stimulate the production of red blood cells. High or low levels of erythropoietin can cause health problems.

Detailed explanation-2: -The recombinant EPO has been demonstrated to correct anemia in patients with severe end stage renal disease and alleviate their transfusion requirements. It has also been studied for anemia associated with HIV infection/zidovudine therapy, in cancer, rheumatoid arthritis, and prematurity.

Detailed explanation-3: -Erythropoietin (Epo) is a glycoprotein hormone produced in the kidney that acts on erythroid progenitor cells in the bone marrow. A negative feedback system, in which tissue oxygenation controls Epo production and Epo controls red blood cell (RBC) production, provides homeostasis in oxygen delivery to body tissues.