PATHOLOGY

Detailed explanation-1: -Podocytes make up the epithelial lining of Bowman’s capsule, the third layer through which filtration of blood takes place. Bowman’s capsule filters the blood, retaining large molecules such as proteins while smaller molecules such as water, salts, and sugars are filtered as the first step in the formation of urine.

Detailed explanation-2: -The measured mean podocyte nuclear caliper diameter values for D were as follows: 8.3±0.6 m for humans (n=12), 7.1±0.4 m for rats (n=10), and 6.9±0.4 m for mice (n=10).

Detailed explanation-3: -The size of the filtration slits restricts the passage of large molecules like serum albumin and cells like red blood cells and platelets. Foot processes of podocytes interconnect with one another forming filtration slits (or slit pores). The size of filtration slits is about 25 nm.