PATHOLOGY

Detailed explanation-1: -The glomerulus has a glomerular basement membrane consisting mainly of laminins, type IV collagen, agrin, and nidogen, which are synthesized and secreted by both endothelial cells and podocytes: thus, the glomerular basement membrane is sandwiched between the glomerular capillaries and the podocytes.

Detailed explanation-2: -The glomerulus is made up of three cell types, the endothelial cells, the podocytes and the mesangial cells (MCs).

Detailed explanation-3: -A glomerulus is the network of capillaries that resides in the Bowman’s capsule that functions as a filtration unit of kidney. The glomerular function ensures that essential plasma proteins are retained in blood and the filtrate is passed on as urine.