PATHOLOGY

Detailed explanation-1: -Reabsorption in the thick ascending limb: A further 25% of the sodium and potassium is reabsorbed through the walls of the thick ascending limb of the loop of Henle via: Three-ion cotransporter (sodium/potassium/chloride) and the sodium/potassium ATPase, which as before maintains the sodium concentration gradient.

Detailed explanation-2: -This part of the nephron is called the loop of Henle. Its main function is to reabsorb water and sodium chloride from the filtrate. This conserves water for the organism, producing highly concentrated urine.

Detailed explanation-3: -In summary, the loop of Henle is surrounded by tissue fluid which has a high concentration of ions in it. This causes water to move out of the descending limb by osmosis. This produces a more concentrated filtrate because of this, ions move out of the loop in the thin ascending limb.