GK
BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Antibody molecule
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Bone-Marrow cells
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T-Cytotoxic cell
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T-Helper cell
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Detailed explanation-1: -HIV binds to the CD4 molecule on the surface of helper T-cells and replicates within them. This results in destruction of CD4+ T-cells and leads to a steady decline in this population of T-cells.
Detailed explanation-2: -CD4 cells (also known as CD4+ T cells) are white blood cells that fight infection. CD4 cell count is an indicator of immune function in patients living with HIV and one of the key determinants for the need of opportunistic infection (OI) prophylaxis.
Detailed explanation-3: -HIV contains a glycoprotein called gp120 that binds onto a glycoprotein called CD4 found on helper T-cells. It then uses another glycoprotein called gp41 to initiate cell-mediated endocytosis. This fuses the viral and cell membrane and brings the viral contents into the cell.