GENERAL KNOWLEDGE

Detailed explanation-1: -Norepinephrine, also known as noradrenaline, is both a neurotransmitter and a hormone. It plays an important role in your body’s “fight-or-flight” response. As a medication, norepinephrine is used to increase and maintain blood pressure in limited, short-term serious health situations.

Detailed explanation-2: -Norepinephrine exerts its effects by binding to -and -adrenergic receptors (or adrenoceptors, so named for their reaction to the adrenal hormones) in different tissues. In the blood vessels, it triggers vasoconstriction (narrowing of blood vessels), which increases blood pressure.

Detailed explanation-3: -Together with adrenaline, norepinephrine increases heart rate and blood pumping from the heart. It also increases blood pressure and helps break down fat and increase blood sugar levels to provide more energy to the body.

Detailed explanation-4: -First norepinephrine markedly affect preload. In 25 septic shock patients who were fluid responsive, as defined by a positive passive leg raising test, norepinephrine increased central venous pressure by 23%, left ventricular end-diastolic area by 9% and global end diastolic volume by 9% (7).