GENERAL KNOWLEDGE

Detailed explanation-1: -The inhalation of nitric oxide improves arterial oxygenation in high-altitude pulmonary edema, and this beneficial effect may be related to its favorable action on the distribution of blood flow in the lungs. A defect in nitric oxide synthesis may contribute to high-altitude pulmonary edema.

Detailed explanation-2: -The higher nitrogen oxides are respiratory irritants. The primary site of toxicity is the lower respiratory tract. Low concentrations initially may cause mild shortness of breath and cough; then, after a period of hours to days, victims may suffer bronchospasm and pulmonary edema.

Detailed explanation-3: -Inhaling nitrous oxide directly from the canister is very dangerous because the gas is under such high pressure and it comes out as extremely cold. This can damage your throat and lungs, stop you breathing or slow your heart to a dangerous level.

Detailed explanation-4: -Nitric oxide has been shown to be clinically effective in the treatment of congenital heart disease, mitrial valvular disease combined with pulmonary hypertension and in orthotropic cardiac transplantation patients.