GENERAL KNOWLEDGE

Detailed explanation-1: -The spleen is a complex organ that is perfectly adapted to selectively filtering and destroying senescent red blood cells (RBCs), infectious microorganisms and Plasmodium-parasitized RBCs. Infection by malaria is the most common cause of spleen rupture and splenomegaly, albeit variably, a landmark of malaria infection.

Detailed explanation-2: -An enlarged spleen can be caused by infections, cirrhosis and other liver diseases, blood diseases characterized by abnormal blood cells, problems with the lymph system, or other conditions. Other causes of an enlarged spleen include: Inflammatory diseases such as sarcoidosis, lupus, and rheumatoid arthritis.

Detailed explanation-3: -Splenic complications identified in cases of malaria are splenic infarction, spontaneous splenic rupture, hyperreactive malarial syndrome, hypersplenism, ectopic spleen and splenic torsion, and splenic cysts. Splenic infarction is not usually noted and is likely underdiagnosed in many cases of complicated malaria.