GK
VITAMINS MINERALS COENZYMES AND DEFICIENCY DISEASES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Dihydroorotate dehydrogenase contains
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2 flavins and 2 atoms of iron per molecule
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2 flavins and 4 atoms of iron per molecule
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4 flavins and 2 atoms of iron per molecule
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4 flavins and 4 atoms of iron per molecule
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Explanation:
Detailed explanation-1: -The dihydroorotate dehydrogenase (DHOD) enzyme catalyzes the unique redox reaction in the de novo pyrimidine biosynthesis pathway. In this reaction, the oxidation of dihydroorotate (DHO) to orotate (OA) and reduction of the flavin mononucleotide (FMN) cofactor is catalysed by DHOD.
Detailed explanation-2: -4.1 Dihydroorotate dehydrogenase (DHODH) inhibitors DHODH is an important rate-limiting enzyme in the de novo synthesis of pyrimidine, which catalyses the conversion of dihydroorotate to orotate and provides nucleotides for the synthesis of RNA/DNA [70, 71].
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