GENERAL KNOWLEDGE

GK

VITAMINS MINERALS COENZYMES AND DEFICIENCY DISEASES

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Wilson’s disease is an example of ____ and Menkes’ syndrome is an example of ____ .
A
zinc toxicity; zinc deficiency
B
zinc deficiency; zinc toxicity
C
copper deficiency; copper toxicity
D
copper toxicity; copper deficiency
Explanation: 

Detailed explanation-1: -Wilson’s disease (WD) is caused by excess of copper that leads to accumulation of copper mainly in the liver, brain and needs life-long decoppering therapy. However, overtreatment with anti-copper agents may lead to copper deficiency which may cause neurological and hematological symptoms.

Detailed explanation-2: -Menkes disease usually causes low copper levels in blood plasma, the liver and the brain. The condition also reduces the activities of copper-dependent enzymes in the body. Copper may accumulate in other tissues, such as the kidney.

Detailed explanation-3: -Wilson’s disease, also known as hepatolenticular degeneration and progressive lenticular degeneration, is a rare genetic disorder that causes copper poisoning in the body. It affects about 1 in 30, 000 people worldwide. In a healthy body, the liver filters out excess copper and releases it through urine.

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