MICROANATOMY

Detailed explanation-1: -The complexity of the Rh blood group antigens begins with the highly polymorphic genes that encode them. There are two genes, RHD and RHCE, that are closely linked. Numerous genetic rearrangements between them has produced hybrid Rh genes that encode a myriad of distinct Rh antigens. To date, 49 Rh antigens are known.

Detailed explanation-2: -What is Rh factor? Rh factor (or Rhesus factor) is a type of protein on the outside or surface of your red blood cells. You inherit the protein, which means you get your Rh factor from your biological parents. If you have the protein, you’re Rh-positive.

Detailed explanation-3: -The D antigen is the most immunogenic, meaning it provokes an immune response that makes it most likely to cause a transfusion reaction in the recipient.