MICROANATOMY

Detailed explanation-1: -Monocytes can differentiate into inflammatory or anti-inflammatory subsets. Upon tissue damage or infection, monocytes are rapidly recruited to the tissue, where they can differentiate into tissue macrophages or dendritic cells.

Detailed explanation-2: -Macrophages are formed through the differentiation of monocytes, one of the major groups of white blood cells of the immune system. When there is tissue damage or infection, the monocytes leave the bloodstream and enter the affected tissue or organ and undergo a series of changes to become macrophages.

Detailed explanation-3: -Monocytes are produced by the bone marrow from precursors called monoblasts, bipotent cells that differentiated from hematopoietic stem cells.

Detailed explanation-4: -Macrophages surround and kill microorganisms, ingest foreign material, remove dead cells, and boost immune responses. During inflammation, dendritic cells boost immune responses by showing antigens on their surface to other cells of the immune system. A monocyte is a type of white blood cell and a type of phagocyte.

Detailed explanation-5: -In tissues, monocytes develop into much larger phagocytic cells known as macrophages.