MICROANATOMY

Detailed explanation-1: -The mating of parents of which two ABO phenotypes can potentially produce offspring with ALL of the common four blood types? Bombay phenotype (Oh) individuals may have antibodies with all the following specificities EXCEPT: Anti-A. Anti-B.

Detailed explanation-2: -Bombay blood group or Oh phenotype is a rare autosomal recessive phenotype within the ABO blood grouping system. It occurs due to a mutation in the H gene that produces H antigen on red blood cells (RBCs). Individuals with two mutant H genes lack H antigen on RBCs and have anti-H antibodies in serum.

Detailed explanation-3: -The HH or Bombay blood group do not produce this H antigen, subsequently not producing either A or B antigen. They only have the ‘H’ antibody which none of the other blood groups has due to which blood transfusion for the Bombay blood with any other group is not possible.

Detailed explanation-4: -The Bombay phenotype is characterized by the absence of A, B, and H antigens on its red cells and the serum of these individuals have anti-A and anti-B [4]. But the serum that agglutinates red cells of ‘O’ group individuals through a wide thermal range may be due to presence of strongly reactive anti-H antibodies [5].

Detailed explanation-5: -Normally it is believed that the rare blood group is O negative, which is very difficult to get because it is found only in selected people. But rather than O negative there is a rarest blood group that is found in any one of the millions of people, and its name is Bombay Blood Group.