MICROANATOMY

Detailed explanation-1: -Fibrin is the insoluble fibrous protein formed from fibrinogen, a soluble protein. Fibrin forms a mesh-like or jelly-like substance at the injury site and ultimately, the blood clot is formed when the red blood cells get entangled with the mesh-like substance.

Detailed explanation-2: -Fibrinogen is a soluble macromolecule, but forms an insoluble clot or gel on conversion to fibrin by the action of the serine protease thrombin, which is activated by a cascade of enzymatic reactions triggered by vessel wall injury, activated blood cells, or a foreign surface (Fig. 13.1).

Detailed explanation-3: -Fibrinogen is a soluble plasma protein that is converted to polymeric fibrin in response to damage to the vascular system. The clotting process is initiated when platelets aggregate at the wound site.

Detailed explanation-4: -Fibrin is produced upon cleavage of the fibrinopeptides by thrombin, which can then form double-stranded half staggered oligomers that lengthen into protofibrils. The protofibrils then aggregate and branch, yielding a three-dimensional clot network.

Detailed explanation-5: -Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood. It is formed by the action of the protease thrombin on fibrinogen, which causes it to polymerize. The polymerized fibrin, together with platelets, forms a hemostatic plug or clot over a wound site.