MICROANATOMY

Detailed explanation-1: -Inflammatory mediators are molecules produced by activated cells that intensify and prolong the inflammatory response. Histamine is a potent inflammatory mediator, commonly associated with allergic reactions, promoting vascular and tissue changes and possessing high chemoattractant activity.

Detailed explanation-2: -Histamine increases the vasodilatation, and also increases the vascular permeability in the immediate transient phase of the acute inflammatory reaction. This act as a chemical mediator in acute inflammation.

Detailed explanation-3: -These cells express histamine receptors and also secrete histamine, which can selectively recruit the major effector cells into tissue sites and affect their maturation, activation, polarization, and effector functions leading to chronic inflammation.

Detailed explanation-4: -They’re chemicals your immune system makes. Histamines act like bouncers at a club. They help your body get rid of something that’s bothering you–in this case, an allergy trigger, or “allergen.” Histamines start the process that hustles those allergens out of your body or off your skin.

Detailed explanation-5: -Mast Cells: Source of Histamine Histamine can also be produced by basophils and other immune cells (28) but much higher concentrations of histamine may be found in intestinal mucosa, skin, and bronchial tissues.