MICROANATOMY

Detailed explanation-1: -Secondary hemostasis (coagulation cascade) Ultimately, the coagulation cascade forms a substance called fibrin. During this step, the platelet plug acts like bricks and the fibrin acts like mortar. Together, they form a solid, stable clot.

Detailed explanation-2: -Fibrin forms long strands of tough insoluble protein that are bound to the platelets. Factor XIII completes the cross-linking of fibrin so that it hardens and contracts. The cross-linked fibrin forms a mesh atop the platelet plug that completes the clot.

Detailed explanation-3: -Fibrinogen and fibrin are essential for hemostasis and are major factors in thrombosis, wound healing, and several other biological functions and pathological conditions.

Detailed explanation-4: -The fibrin network is the main structural component of the blood clot and stabilizes the platelet plug that forms upon a vascular injury (3, 7–10). The formation of the network occurs in a sequence of steps, starting with the conversion of fibrinogen to fibrin, enzymatically catalyzed by thrombin (11, 12).