MICROANATOMY

Detailed explanation-1: -The kidneys and liver produce erythropoietin when oxygen levels in the cells are low. The hormone then stimulates the bone marrow, which, in turn, makes more red blood cells. It is normal for a small amount of erythropoietin to circulate in the blood, as this helps replenish the body’s natural blood stores.

Detailed explanation-2: -Lack of O2 (hypoxia) is a stimulus for the synthesis of erythropoietin (Epo), primarily in the kidneys.

Detailed explanation-3: -Normally, when specialized cells in your kidneys detect low blood oxygen levels, they increase the production of EPO. EPO then tells the spongy tissue inside your bones (bone marrow) to make more red blood cells.

Detailed explanation-4: -Erythropoietin (EPO) is required for red blood cell production. EPO is produced in the kidney in a hypoxia dependent manner and is secreted into the circulation. EPO is the primary regulator for production of red blood cells that transport oxygen in the circulation from the lungs to the tissues.