BLOOD CARDIOVASCULAR SYSTEM LYMPHOID ORGANS
BLOOD
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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a lack of red blood cells
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a genetic abnormality in the amino acids
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lack of available oxygen
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too much iron in the circulatory system
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Detailed explanation-1: -Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation in the -globin gene resulting in the substitution of the amino acid valine for glutamic acid in the -globin chain.
Detailed explanation-2: -Sickle cell anemia is caused by homozygous sickle mutation (Hb SS). The sickle mutation causes substitution of a valine for glutamic acid as the seventh amino acid of the beta globin chain. The resulting hemoglobin tetramer (alpha2/betaS2) is poorly soluble when deoxygenated.
Detailed explanation-3: -Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11. Hemoglobin transports oxygen from the lungs to other parts of the body. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and round and glide through blood vessels.