MICROANATOMY

Detailed explanation-1: -Leukocyte extravasation (also commonly known as leukocyte adhesion cascade or diapedesis – the passage of cells through the intact vessel wall) is the movement of leukocytes out of the circulatory system and towards the site of tissue damage or infection.

Detailed explanation-2: -The innate immune response involves the extravasation of leukocytes from blood vessels to sites of tissue damage, infection, or inflammation, a process known as diapedesis (1–3). This complex process is regulated spatiotemporally by many receptor molecules in both leukocytes and vascular endothelial cells (VECs).

Detailed explanation-3: -Leukocytes function in body defenses. They squeeze out of the walls of blood vessels through emigration or diapedesis, then may move through tissue fluid or become attached to various organs where they fight against pathogenic organisms, diseased cells, or other threats to health.

Detailed explanation-4: -TEM, or diapedesis, is the process whereby the leukocyte squeezes in ameboid fashion across the endothelial cells. This almost always happens at endothelial cell borders101, 117 (a small fraction of transmigration occurs through the endothelial cell body; this will be discussed later).

Detailed explanation-5: -The process of WBCs squeezing out is called diapedesis, while the process of the WBCs engulfing these antigens is called phagocytosis.