MICROANATOMY

Detailed explanation-1: -Erythropoietin (EPO) is a glycoprotein hormone, naturally produced by the peritubular cells of the kidney, that stimulates red blood cell production. Renal cortex peritubular cells produce most EPO in the human body. PO2 directly regulates EPO production.

Detailed explanation-2: -Healthy kidneys produce a hormone called erythropoietin or EPO, which stimulates the bone marrow to make red blood cells needed to carry oxygen (O2) throughout the body.

Detailed explanation-3: -ERYTHROPOIESIS is known to be stimulated by several hormonal substances. ACTH, 1, 2 adrenocortical steroids, 3, 4thyrotrophic and thyroid hormones, 1, 5 growth hormone3 and testosterone6are hormones that have been shown to stimulate erythropoiesis in either intact or hypophysectomized rats.

Detailed explanation-4: -The cytokine erythropoietin (EPO) is required for production of red blood cells. In the human body, EPO stimulates the daily production of about 200 billion new red blood cells to compensate for the limited red blood cell lifespan of 110–120 days (Figure 1).