MICROANATOMY

Detailed explanation-1: -Erythropoietin (EPO) is a glycoprotein hormone, naturally produced by the peritubular cells of the kidney, that stimulates red blood cell production. Renal cortex peritubular cells produce most EPO in the human body. PO2 directly regulates EPO production.

Detailed explanation-2: -The hormone erythropoietin (Epo) maintains red blood cell mass by promoting the survival, proliferation and differentiation of erythrocytic progenitors.

Detailed explanation-3: -Peptide hormone erythropoietin secreted from the juxtaglomerular cells of kidney stimulates erythropoiesis.

Detailed explanation-4: -The renal glycoprotein hormone erythropoietin (Epo) is the key element in the feedback control of the production of red blood cells (RBC) in bone marrow. Excess of antidiuretic hormone (ADH) increases the RBC mass by increasing the synthesis of Epo.