MICROANATOMY

Detailed explanation-1: -The mechanism of hemostasis can divide into four stages. 1) Constriction of the blood vessel. 2) Formation of a temporary “platelet plug.” 3) Activation of the coagulation cascade. 4) Formation of “fibrin plug” or the final clot.

Detailed explanation-2: -Haemostasis is the physiological process by which bleeding ceases. Haemostasis involves three basic steps: vascular spasm, the formation of a platelet plug, and coagulation, by which clotting factors promote the formation of a fibrin clot.

Detailed explanation-3: -Primary hemostasis is the formation of a weak platelet plug which is achieved in four phases: vasoconstriction, platelet adhesion, platelet activation, and platelet aggregation. Vasoconstriction is the initial response whenever there is vessel injury.

Detailed explanation-4: -Hemostasis may be categorized into primary (platelet plug formation), secondary (formation of a stabilized fibrin clot through the coagulation cascade), and tertiary (formation of plasmin for breakdown of fibrin via fibrinolysis) concurrent processes.

Detailed explanation-5: -Vascular spasm is the first response as the blood vessels constrict to allow less blood to be lost. In the second step, platelet plug formation, platelets stick together to form a temporary seal to cover the break in the vessel wall. The third and last step is called coagulation or blood clotting.