MICROANATOMY

Detailed explanation-1: -With primary thrombocythemia, a high platelet count may happen alone or with other blood cell disorders. This condition is not common. Thrombocythemia is most often caused by your genes. Mutations, or changes, in the genes that control how your bone marrow forms platelets may cause thrombocythemia.

Detailed explanation-2: -A false increase of the platelet count can be observed in the presence of non-platelet particles (as small as platelets), such as fragmented erythrocytes, fragments of nucleated cells, bacteria, fungi, lipids, and cryoglobulins.

Detailed explanation-3: -Abstract. Pseudothrombocytopenia (PTCP) is an in vitro phenomenon of low platelet count caused by the agglutination of platelets, leading to false low platelet counts in automated cell counting. Typically, ethylenediaminetetraacetic acid (EDTA) mediates this platelet clumping.

Detailed explanation-4: -The causes of false thrombocytopenia may be: abnormal mixing of studied blood with anticoagulant, EDTA-dependent antibodies, satellite thrombocytes around leucocytes. Searching for false thrombocytopenia, thrombocyte count was examined in 477 children without signs of haemorrhagic diathesis.