MICROANATOMY

Detailed explanation-1: -Hint: The extrinsic pathway begins with a substance called tissue factor (tissue thromboplastin) released by damaged blood vessels and surrounding tissues. In the presence of other plasma proteins (clotting factors) and calcium ions, this leads to the activation of a protein called factor X.

Detailed explanation-2: -Role of TF in Thrombosis. Aberrant TF expression triggers intravascular thrombosis associated with various diseases, such as atherosclerosis, cancer, and sepsis (reviewed in14–17).

Detailed explanation-3: -Thrombin converts fibrinogen to fibrin, which recruits elements of the blood to form a clot. Explanation: Thromboplastin is released when damage occurs to a tissue.

Detailed explanation-4: -Thromboplastin is found in brain, lung, and other tissues and especially in blood platelets. Although sometimes used as a synonym for the protein tissue factor (with its official name “Coagulation factor III [thromboplastin, tissue factor]"), this is a misconception.