MICROANATOMY

Detailed explanation-1: -Polycythemia, also called erythrocytosis, refers to increased red blood cell mass, noted on laboratory evaluation as increased hemoglobin and hematocrit levels. Polycythemia vera is a subtype of polycythemia and can be associated with the overproduction of more than just the erythrocytic lineage.

Detailed explanation-2: -Polycythemia vera is a rare blood disorder in which there is an increase in all blood cells, particularly red blood cells. The increase in blood cells makes the blood thicker. Thick blood can lead to strokes or tissue and organ damage.

Detailed explanation-3: -In polycythemia, the levels of hemoglobin (Hgb), hematocrit (Hct), or red blood cell (RBC) count may be elevated when measured in the complete blood count (CBC), as compared to normal. Hemoglobin levels greater than 16.5 g/dL (grams per deciliter) in women and greater than 18.5 g/dL in men suggest polycythemia.

Detailed explanation-4: -Polycythaemia, also known as erythrocytosis, means having a high concentration of red blood cells in your blood. This makes the blood thicker and less able to travel through blood vessels and organs.

Detailed explanation-5: -Polycythemia vera is due to mutations involving JAK2, or rarely CALR or LNK mutations in hematopoietic stem cells that lead to sustained activation of JAK2 kinase, which causes excess blood cell production.