MICROANATOMY

Detailed explanation-1: -Thalassemia is a heterogeneous group of blood disorders affecting the hemoglobin genes and resulting in ineffective erythropoiesis. The decreased production of hemoglobin results in anemia in early age and frequent blood transfusions are required to keep up the hemoglobin levels.

Detailed explanation-2: -Thalassemia is an inherited (i.e., passed from parents to children through genes) blood disorder caused when the body doesn’t make enough of a protein called hemoglobin, an important part of red blood cells.

Detailed explanation-3: -Inherited hemoglobin disorders fall into two main groups: the structural hemoglobin variants and the thalassemias, which are caused by defective globin production. They all follow a recessive form of inheritance. Those with a single defective globin gene-carriers or heterozygotes-are symptomless.

Detailed explanation-4: -There are 2 main types of thalassemia: alpha and beta. Different genes are affected for each type. Thalassemia can cause mild or severe anemia. Anemia occurs when your body does not have enough red blood cells or hemoglobin.