MICROANATOMY

Detailed explanation-1: -Sickle cell anemia is caused by a change in the gene that tells the body to make the iron-rich compound in red blood cells called hemoglobin. Hemoglobin enables red blood cells to carry oxygen from the lungs throughout the body.

Detailed explanation-2: -Sickling process The sickling occurs because of a mutation in the hemoglobin gene. It begins with the substitution of valine for glutamic acid at the sixth position of the beta-globin chain. The association of heme plus 2 normal -globin and 2 abnormal -globin chains forms Hb S.