MICROANATOMY

Detailed explanation-1: -Fibrinolysis efficiency is greatly influenced by clot structure, fibrinogen isoforms and polymorphisms, the rate of thrombin generation, the reactivity of thrombus-associated cells such as platelets, and the overall biochemical environment.

Detailed explanation-2: -PA is the major component of the fibrinolytic system and includes t‐PA and urokinase plasminogen activator (u‐PA). t‐PA is a key enzyme in blood vessels that is synthesised primarily in endothelial cells and stored, and used to treat thrombosis.

Detailed explanation-3: -Fibrinolysis is the enzymatic breakdown of fibrin in blood clots. Plasmin cuts the fibrin mesh at various places, leading to the production of circulating fragments that are cleared by other proteases. Primary fibrinolysis is a normal body process.

Detailed explanation-4: -This activation occurs through cleavage of an Arg-Val peptide bond within plasminogen giving rise to the active protease, plasmin. [1] This cleavage event is the similar activating step for all the different activators of plasminogen, of which tPA is the most ubiquitous.