MICROANATOMY

Detailed explanation-1: -Hemolytic transfusion reactions (HTRs) are reactions in which donor RBCs are destroyed by antibodies in the recipient’s circulation. They occur when antigen-positive donor RBCs are transfused into a patient who has preformed antibodies to that antigen.

Detailed explanation-2: -To work out your blood group, your red cells are mixed with different antibody solutions. If, for example, the solution contains anti-B antibodies and you have B antigens on your cells (you’re blood group B), it will clump together.

Detailed explanation-3: -The agglutinated red cells can clog blood vessels and stop the circulation of the blood to various parts of the body. The agglutinated red blood cells can also crack open, leaking toxic contents out in the body, which can have fatal consequences for the patient.

Detailed explanation-4: -Mixing blood from two individuals can lead to blood clumping or agglutination. The clumped red cells can crack and cause toxic reactions. This can have fatal consequences.

Detailed explanation-5: -The agglutination indicates that the blood has reacted with a certain antibody and is therefore not compatible with blood containing that kind of antibody. If the blood does not agglutinate, it indicates that the blood does not have the antigens binding the special antibody in the reagent.