MICROANATOMY

Detailed explanation-1: -The “glue” that holds platelets to the blood vessel wall is von Willebrand factor, a large protein produced by the cells of the vessel wall. The proteins collagen and thrombin act at the site of the injury to induce platelets to stick together.

Detailed explanation-2: -Antiplatelet drugs prevent platelets from sticking together and decrease your body’s ability to form blood clots. These medications are used to treat, and may help prevent, heart attack and stroke. Aspirin is the most commonly used antiplatelet drug.

Detailed explanation-3: -Platelet adhesion The initial event that occurs upon hemostasis is the rolling and adherence of the platelets to the exposed subendothelium. Platelet adhesion is mediated by von Willebrand Factor (vWF) that binds to Gp Ib-IX in the platelet membrane.