MICROANATOMY

Detailed explanation-1: -If you have HIV, a low CD4 count means that HIV has weakened your immune system. A CD4 count of 200 or fewer cells per cubic millimeter means that you have AIDS. With AIDS you have a high risk of developing life-threatening infections or cancers. If you don’t have HIV, a low CD4 count may be caused by an infection.

Detailed explanation-2: -In the natural history of HIV infection, there is an initial decrease in the number of TCD4 lymphocytes that relates to the clinical primary infection (2 weeks after infection); then a partial recovery occurs, due to atypical lymphocytes and to an increase in T CD8 lymphocytes (3–4 weeks after exposure).

Detailed explanation-3: -Once HIV infection occurs, the body’s immune system is damaged resulting in decreased CD4+ T lymphocyte and dysfunction as well as increased CD8+ T lymphocyte levels, eventually leading to CD4+/CD8+ imbalance. Therefore, the main assessment indicator is immune system damage condition in AIDS patients.