MICROANATOMY

Detailed explanation-1: -Polymorphonuclear neutrophils (PMNs) are the most abundant leukocytes in the circulation, and the first cellular responders to tissue injury and infection.

Detailed explanation-2: -Neutrophils are first responders of the immune system, rapidly migrating into affected tissues in response to injury or infection.

Detailed explanation-3: -O negative is called the ‘universal’ blood type because it’s the only one that can be given to anyone in an emergency, which is why it’s carried by paramedics and air ambulances, ready to be used at accident scenes. As an O negative blood donor, you are a part of the emergency services – a First Responder.

Detailed explanation-4: -Neutrophils, constituting the first line of defense, perform vital functions during immune surveillance. A key feature that assists in their prompt response to an inflammatory signal is rapid migration to the affected site.

Detailed explanation-5: -2 Despite the different etiologies of these injuries, the resultant immune response is surprisingly similar. Next, neutrophils, monocytes and mature macrophages are recruited within the first few hours of injury, with neutrophils usually considered as the first responders.