MICROANATOMY

Detailed explanation-1: -Von Willebrand factor (VWF) is an adhesive multimeric glycoprotein that is crucial for normal hemostasis. The best-known functions of VWF are facilitating platelet adhesion at sites of vascular injury and protecting clotting factor VIII against early degradation in the circulation.

Detailed explanation-2: -von Willebrand factor (VWF) and platelets are key mediators of normal hemostasis. At sites of vascular injury, VWF recruits platelets via binding to the platelet receptor glycoprotein Ib (GPIb).

Detailed explanation-3: -GPIb-IX-V plays a key role in the process of platelet recruitment to the site of vascular injury through specific engagement of the A1 domain of immobilized VWF. This adhesive interaction supports initial platelet tethering and translocation that is insufficient to support firm adhesion.

Detailed explanation-4: -Platelet adhesion is mediated by von Willebrand Factor (vWF) that binds to Gp Ib-IX in the platelet membrane. vWF is a blood Gp that serves as an adhesive protein, which could bind to other proteins, especially factor VIII at the wound sites 10, 16-17, 19.