MICROANATOMY

Detailed explanation-1: -To accomplish that, platelets that circulate in your blood stick to the damaged tissue and activate. That activation means they can “recruit” more platelets to form a platelet “plug” to stop blood loss from the damaged area.

Detailed explanation-2: -The process of spreading across the surface of a damaged blood vessel to stop bleeding is called adhesion. This is because when platelets get to the site of the injury, they grow sticky tentacles that help them stick (adhere) to one another.

Detailed explanation-3: -The mechanism of hemostasis can divide into four stages. 1) Constriction of the blood vessel. 2) Formation of a temporary “platelet plug.” 3) Activation of the coagulation cascade. 4) Formation of “fibrin plug” or the final clot.

Detailed explanation-4: -In the second step, platelets, which normally float free in the plasma, encounter the area of vessel rupture with the exposed underlying connective tissue and collagenous fibers. The platelets begin to clump together, become spiked and sticky, and bind to the exposed collagen and endothelial lining.

Detailed explanation-5: -Hemostasis is triggered by the exposure of blood to a breach in the vessel wall. During the initiation phase, circulating platelets are recruited to the injury site via adhesive interactions between von Willebrand factor (vWf) bound to collagen fibers in the vessel wall and the platelet GPIb-IX-V receptor complex.