MICROANATOMY

Detailed explanation-1: -The liver forms at day 8 of embryogenesis. During this period, this organ is part of the cardiovascular system through its hematopoietic function, and by interconnecting the early placental vessels with the heart.

Detailed explanation-2: -Hematopoiesis occurs in the fetal liver and spleen. Hematopoietic stem and progenitor cells in the fetal liver migrate to the bone marrow and the marrow becomes the major hematopoietic site after birth.

Detailed explanation-3: -During this period the liver is colonized by undifferentiated hematopoietic stem cells (HSCs) that gradually differentiate and once mature, enter the circulatory system through the hepatic sinusoids, this process is called hepatic hematopoiesis.

Detailed explanation-4: -Hematopoiesis in the embryo As the embryo continues to develop, the hematopoiesis process moves to the liver, the spleen, and bone marrow, and begins producing other types of blood cells. In adults, hematopoiesis of red blood cells and platelets occurs primarily in the bone marrow.