MICROANATOMY

Detailed explanation-1: -Normally, when specialized cells in your kidneys detect low blood oxygen levels, they increase the production of EPO. EPO then tells the spongy tissue inside your bones (bone marrow) to make more red blood cells.

Detailed explanation-2: -The glycoprotein hormone erythropoietin (EPO) counteracts tissue hypoxia by increasing the systemic oxygen-carrying capacity. It induces augmentation of red blood cell mass by stimulating the formation and differentiation of erythroid precursor cells in the bone marrow.

Detailed explanation-3: -Erythropoietin (EPO) is the key hormone responsible for effective erythropoiesis, and iron is the essential mineral required for hemoglobin production. EPO allows survival and proliferation of erythroid precursor cells by generating intracellular signals resulting in the prevention of apoptosis.