BLOOD CARDIOVASCULAR SYSTEM LYMPHOID ORGANS
LYMPH NODES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Produce histamine and leukotrines
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Use perforins to rupture the membranes of pathogens
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Are the most abundant phagocytic WBS’s
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Pick up foreign material and take it to the nearest lymph node
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Detailed explanation-1: -The role of human basophils and mast cells in the pathogenesis of allergic diseases has been analyzed. Purified human basophils and mast cells release several known mediators of allergic reactions, including histamine, sulfidopeptide leukotrienes, kinin-forming enzymes, and, in the case of the mast cell, PGD2.
Detailed explanation-2: -Mast cells are now thought to exert critical proinflammatory functions, as well as potential immunoregulatory roles, in various immune disorders through the release of mediators such as histamine, leukotrienes, cytokines chemokines, and neutral proteases (chymase and tryptase).
Detailed explanation-3: -Mast cells and basophils represent the most relevant source of histamine in the immune system. Histamine is stored in cytoplasmic granules along with other amines (e.g., serotonin), proteases, proteoglycans, cytokines/chemokines, and angiogenic factors and rapidly released upon triggering with a variety of stimuli.
Detailed explanation-4: -Activated basophils and mast cells release both overlapping and unique sets of inflammatory mediators, including histamine, proteoglycans, lipid mediators, proteases, chemokines, growth factors and cytokines [9].