MICROANATOMY

Detailed explanation-1: -The lymph node is composed of sinuses that allow travel of lymph, the cortex and paracortex composed of T and B lymphocytes, and the medulla consisting of plasma cells and macrophages (Figure 7).

Detailed explanation-2: -There are two major types of T cells: the helper T cell and the cytotoxic T cell. As the names suggest helper T cells ‘help’ other cells of the immune system, whilst cytotoxic T cells kill virally infected cells and tumours.

Detailed explanation-3: -The majority of mature B cells outside of the GALT reside within lymphoid follicles of the spleen and lymph nodes, where they encounter and respond to T cell–dependent foreign antigens bound to follicular dendritic cells (DCs), proliferate, and either differentiate into plasma cells or enter GC reactions.