BLOOD CARDIOVASCULAR SYSTEM LYMPHOID ORGANS
LYMPH NODES
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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T-Cells
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B-Cells
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Both
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None of the above
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Detailed explanation-1: -Helper T cells stimulate the B cell through the binding of CD40L on the T cell to CD40 on the B cell, through interaction of other TNF-TNF-receptor family ligand pairs, and by the directed release of cytokines.
Detailed explanation-2: -B cell activating factor (BAFF) is a cytokine and member of the TNF family. It is produced by a wide variety of cells (neutrophils, monocytes, macrophages, DCs, and T Cells) (49). It is essential for the maturation and survival of the B Cells since it participates in the processes of differentiation and proliferation.
Detailed explanation-3: -The generation of interferon (IFN)-/ and IL-12 cytokines in response to an intracellular pathogen (i.e., viruses and mycobacterium tuberculosis) stimulates responding T cells to induce the expression of the transcription factor T-bet (65).
Detailed explanation-4: -Helper T cells secrete cytokines that help B cells differentiate into plasma cells. These cells also help to activate cytotoxic T cells and macrophages.