MICROANATOMY

Detailed explanation-1: -blood group O – has no antigens, but both anti-A and anti-B antibodies in the plasma. blood group AB – has both A and B antigens, but no antibodies.

Detailed explanation-2: -Blood group O has no antigens, but has both anti-A and anti-B antibodies in the plasma, as well as some special “anti-A, B” antibodies. Blood group AB has both A and B antigens, but no antibodies. Blood group B has B antigens with anti-A antibodies in the plasma.

Detailed explanation-3: -Group AB individuals have neither anti-A nor anti-B antibodies in their plasma. Group AB plasma can therefore be given to patients of any ABO blood group and is often referred to as the universal plasma donor.

Detailed explanation-4: -Individuals who are homozygous for null alleles at this locus (h/h) do not produce H antigen, and because the H antigen is an essential precursor to the ABO blood group antigens, they cannot produce A and B antigens. Therefore, their serum contains anti-A and anti-B, in addition to potent anti-H.

Detailed explanation-5: -ABO antigens are added to N-linked oligosaccharide chains on the VWF subunit. Thus patients with the type O blood group genotype lack the functional glycosyltransferase that adds N-acetylgalactosamine and D-galactose to the H antigen on VWF in blood group A and B subjects, respectively.