MICROANATOMY

Detailed explanation-1: -B-cell development is dependent on the nonlymphoid stromal cells of the bone marrow; stem cells isolated from the bone marrow and grown in culture fail to differentiate into B cells unless bone marrow stromal cells are also present.

Detailed explanation-2: -Plasma cells: Plasma cells release antibodies in response to antigens. Once a B-cell becomes a mature plasma cell, it can release up to 2, 000 antibodies per second. Plasma cells are also called plasmacytes or effector cells. They have a shorter lifespan than memory cells.

Detailed explanation-3: -B lymphocytes originate in the bone marrow; their goal is to recognize an antigen. Each of them responds to the antigen in a specific way, as it expresses specific antibodies on the membrane (IgM, CD79a, and CD79b).